Tumor Stromal Phenotypes Define VEGF Sensitivity—Response
نویسندگان
چکیده
منابع مشابه
Tumor stromal architecture can define the intrinsic tumor response to VEGF-targeted therapy.
PURPOSE The aim of the study was to investigate the vascular and stromal architecture of preclinical tumor models and patient tumor specimens from malignancies with known clinical outcomes to VEGFi treatment, to gain insight into potential determinants of intrinsic sensitivity and resistance. EXPERIMENTAL DESIGN The tumor stroma architecture of preclinical and clinical tumor samples were anal...
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Running title: Tumour-stromal phenotypes define VEGF sensitivity Conflict of interest statement: All authors are current or former AstraZeneca employees and shareholders. There are no other conflicts of interest to disclose. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Translational Relevance VEGF pathway inhibitors (VEGFi) are approved f...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2014
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-14-0681